TASS: A new strategy for combating inflammation in cancerous tumors to be developed in Volgograd

4.04.2026

This will make it possible to "artificially" deprive the tumor of its ability to grow and recover, said Boris Gladkikh, a researcher at VSTU

A new strategy for combating inflammation in cancerous tumors, being developed by scientists at Volgograd State Technical University (VSTU), will make it possible to "artificially" deprive the tumor of its ability to grow and recover. This was reported to TASS by Boris Gladkikh, a researcher at VSTU.

"We are synthesizing small molecules capable of selectively inhibiting the enzyme sEH (soluble epoxide hydrolase), which plays a key role in the metabolism of biologically active lipids. High sEH activity often provokes chronic inflammation and helps cancer cells metastasize. By blocking this enzyme, we essentially destroy the tumor's inflammatory shield," explained Gladkikh.

According to the scientist, the multifunctional molecules being developed are capable of depriving the tumor of its ability to adapt and recover after damage, as well as making it sensitive again to standard treatment protocols (chemo- and radiotherapy).

"Our project aims to create original drug candidates for targeted therapy. This approach holds promise for the treatment of a wide range of solid tumors, including aggressive and difficult-to-treat forms such as triple-negative breast cancer, lung cancer, prostate cancer, and colorectal cancer," the researcher added.

Earlier, TASS reported that for effective cancer treatment, Volgograd scientists are also developing innovative compounds – inhibitors that target a specific region of the BRCA1 protein and will make it possible to block the defense systems of tumor cells.

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